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sphingosine and sphingosine-1-phosphate metabolism

State Icon Reaction EC-Number Confidence maximal confidence score from EnzymeDetector
ceramide + H2O <=> sphingosine + fatty_acid 3.5.1.23 ceramidase

palmitoyl-CoA + NADP+ <=> trans-2-hexadecenoyl-CoA + NADPH + H+ 1.3.1.38 trans-2-enoyl-CoA reductase (NADPH)
1.3.1.8 acyl-CoA dehydrogenase (NADP+)


2-trans-hexadecenal + NAD+ + H2O <=> (2E)-hexadecenoate + NADH + H+ 1.2.1.3 aldehyde dehydrogenase (NAD+)

(2E)-hexadecenoate + CoA + ATP <=> trans-2-hexadecenoyl-CoA + diphosphate + AMP 6.2.1.3 long-chain-fatty-acid---CoA ligase

sphingosine_1-phosphate + H2O <=> sphingosine + phosphate 3.1.3
3.1.3.4 phosphatidate phosphatase


sphingosine_1-phosphate <=> 2-trans-hexadecenal + Phosphoethanolamine 4.1.2
4.1.2.27 sphinganine-1-phosphate aldolase
4.3.2



hexadecanal + NADP+ <=> 2-trans-hexadecenal + NADPH + H+ 1.3.1.27 2-hexadecenal reductase

sphingosine + ATP <=> H+ + sphingosine_1-phosphate + ADP 2.7.1.91 sphingosine kinase

hexadecanal + NAD+ + H2O <=> fatty_acid + NADH + H+ 1.2.1.3 aldehyde dehydrogenase (NAD+)
1.2.1.47 4-trimethylammoniobutyraldehyde dehydrogenase
1.2.1.48 long-chain-aldehyde dehydrogenase
1.2.1.5 aldehyde dehydrogenase [NAD(P)+]




fatty_acid + CoA + ATP <=> stearoyl-CoA + AMP + diphosphate 1.13.12.7 firefly luciferase
6.2.1.12 4-coumarate---CoA ligase
6.2.1.3 long-chain-fatty-acid---CoA ligase
6.2.1.30 phenylacetate---CoA ligase
6.2.1.B3





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